In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.
Our results demonstrated that MTHFR rs1801133 C>T was associated with the risk of ESCC; however, MTHFR rs4845882 G>A and rs4846048 A>G SNPs were associated with the decreased risk of ESCC, and MTHFR rs3753584 A>G and rs9651118 T>C SNPs were not associated with ESCC risk.
In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.